Current Clinical Trials

A Reliable Resource

The clinical trials listed below are official trials listed on the website www.ClinicalTrials.gov, a US federally sponsored collaboration between the Food and Drug Administration (FDA) and the National Library of Medicine (NLM) section of the National Institutes of Health (NIH). The sponsor of a clinical trial is obligated by law to include accurate information including registration information, reporting of results and adverse events. Penalties exist for non-compliance.

Clinical Trial Phases

Phase I – New drug in a small group of people for safety, safe dose range and side effects

Phase II – Drug/treatment given to a larger group of people for efficacy and further safety evaluation

Phase III – Drug/treatment given to large group of people to confirm effectiveness, monitor       side effects, collect information before going to market. Confirmation here leads to seeking market approval for sale to the public at large.

Phase IV – After drug/treatment is on the market. Gathering of information on its effect in various populations and to study possible side-effects of long-term use.

 

Current Canadian Clinical Trials

 

Intervention

Phase

Company

Mode of Action

Trial Status (Recruitment)

Sites Involved

Rasagiline

II

Yunxia Wang, MD

Blocks monoamine oxidase and reduces dopamine processing

active

(closed)

Canada, U.S.

 

Other ALS Clinical Trials (ask your clinician about these)

 

Intervention

Phase

Company

Mode of Action

Trial Status (Recruitment)

Sites Involved

CK 2017357, 2, 3

II

Cytokinetics

Amplifies muscle strength by increasing response to stimulation

Completed (awaiting Phase III)

U.S. so far

GSK1223249

I

GlaxoSmithKline

Diminishes levels of a neuronal growth inhibitor Nogo A

Completed (awaiting Phase II)

U.S. so far

 

International ALS Clinical Trials

 

Intervention

Phase

Company

Mode of Action

Trial Status (Recruitment)

Sites Involved

NP 001

II

Neuraltus Pharmaceuticals Inc.

Reduces neuroinflammation by regulating macrophages

active

(closed)

U.S.

KNS 760704

II

Knopp Neurosciences

Identical to dexpramipexole

active

(closed)

U.S.

 

MCI 186

III

Mitsubishi Tanabe Pharma Corporation

Neutralizes free radicals

active

(open)

Japan

Tauroursodeoxycholic Acid

III

Istittuto Nazionale Carlo Besta

Found in normal human digestive bile

Inhibits cell death in neurons

active

(closed)

Italy

Phrenic Stimulation

III

Assistance Publique – Hôpitaux de Paris

Simulates nerves controlling diaphragm to assist breathing without a mechanical ventilator

(diaphragm pacing)

not yet open

France

Creatine and Tamoxifen

II

Nazem Atassi (Massachusetts General Hospital)

Creatine helps supply energy for muscle use

Tamoxifen blocks estrogen action

active

(closed)

U.S.

Transcranial Direct Stimulation

II

Universita degli Studi ‘G. d’Annunzio Chieti e Pescara

Small electrodes deliver constant, low level electrical current to brain area of interest

not yet open

Italy

Dopamine and Serotonin Transporters

III

Assistance Publique – Hopitaux de Paris

Enhance nerve signal transduction

active

(open)

France

Pyrimethamine

I/II

Weill Medical College of Cornell University

Reduces SOD1 levels

active

(open)

(for SOD1 familial ALS)

U.S., Italy, Sweden

Arimoclomol

II/III

University of Miami

Increases neuronal ability to produce self-protective substances

active

(open)

(for SOD1 familial ALS)

U.S.

sNN0029

I/II

NeuroNova AB

Contains neuroprotective VEGF

active

(open)

Belgium

High Fat/Calorie Diet

II

Massachusetts General Hospital

Dietary supplementation

active

(open)

U.S.

E0302 (mecobalamin)

II/III

Eisai Co., Ltd.

Neuroprotective formulation of Vitamin B12

active

(open)

Japan

Supported Treadmill Ambulation Training

I/II

Carolinas Healthcare System

Supervised exercise training with partial weight support

recruiting

(open)

U.S.

Stem Cells

I/II

Brainstorm Cell Therapeutics Ltd.

Autologous cultured mesenchymal bone marrow stromal cells secreting neurotrophic factors

active

(open)

Israel

Stem Cells

I/II

Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia

Autologous bone marrow stem cells

active

(open)

Spain

Stem Cells

I/II

Corestem, Inc.

Autologous bone marrow derived stem cell treatment

active

(open)

Korea

Stem Cells

I

Mayo Clinic

Intrathecal autologous mesenchymal stem cell therapy

active

(open)

U.S.

Stem Cells

I

Mayo Clinic

Dose-escalation using intrathecal autologous mesenchymal stem cell therapy

active

(open)

U.S.

Stem Cells

I

TCA Cellular Therapy

Human neural stem cell transplantation

active

(open)

Italy

Stem Cells

I

Neuralstem Inc.

Human spinal cord derived neural stem cell transplantation

active

(closed)

U.S.